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GHRP-2 vs GHRP-6
Growth HormoneGHRP-2 and GHRP-6 are first and second-generation growth hormone releasing peptides that work through the ghrelin receptor. The key difference is appetite: GHRP-6 dramatically increases hunger through strong ghrelin stimulation, making it useful for those wanting to bulk. GHRP-2 provides similar GH release with significantly less appetite stimulation. Both raise cortisol and prolactin more than Ipamorelin.
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Side-by-Side Comparison
| Aspect | GHRP-2 | GHRP-6 |
|---|---|---|
| dosing | 100-300 mcg SubQ 2-3x daily on empty stomach | 100-300 mcg SubQ 2-3x daily on empty stomach |
| appetite | Moderate increase — manageable for most users | Intense increase — strong hunger within 20 minutes of injection |
| best for | GH elevation without excessive hunger, moderate cortisol/prolactin increase acceptable | Bulking phases where increased appetite is desired, strong GH boost |
| mechanism | GHS-R agonist — potent GH release with moderate ghrelin activation, less appetite stimulation | GHS-R agonist — strong GH release with robust ghrelin activation, significant appetite stimulation |
| fda status | Not FDA-approved; research peptide | Not FDA-approved; research peptide |
| gh release | Strong — slightly higher peak GH than GHRP-6 in some studies | Strong — robust GH pulse, comparable to GHRP-2 |
| side effects | Elevated cortisol and prolactin (less than GHRP-6), water retention, lethargy | Intense hunger, elevated cortisol and prolactin, water retention, lethargy |
Verdict
GHRP-2 for GH elevation without extreme hunger. GHRP-6 for bulking when appetite increase is a feature, not a bug. Both are superseded by Ipamorelin for cleaner GH release.