5-Amino-1MQ

5-Amino-1MQ is a lipophilic small molecule that inhibits the enzyme NNMT, enhancing energy metabolism and promoting fat loss while preserving lean muscle. Preclinical studies show notable effects on adipose tissue, cholesterol reduction, and enhanced mitochondrial function. It is being explored in preclinical models for potential fat loss and metabolic modulation.

• Inhibits nicotinamide N-methyltransferase (NNMT)
• Reduces fat cell size and promotes adipose tissue metabolism
• Preserves muscle mass during caloric restriction
• May enhance NAD+ salvage pathway by reducing methylation drain

• unit: mg

  low dose: 50

  frequency: Daily

  high dose: 150

  standard dose: 100

  administration route: Oral

• Cycle 20–30 days on, followed by 1–2 weeks off to maintain response. Benefits may diminish beyond 8–12 weeks continuous use due to tolerance development. Consider pairing with NAD+ protocols cautiously.

common: ["Nausea, especially at doses above 100 mg/day","Fatigue, lethargy, drowsiness","Dizziness, headache","Sleeplessness if not taken in morning"]

warnings: ["Sedation severe enough to require napping at high initial doses (user-reported)"]

half life: Not precisely defined in humans; estimates suggest moderate duration of action based on dosing frequency

degradation: Metabolized hepatically and excreted renally

molecular weight: 138.17

molecular formula: C7H10N2O

tissue specificity: Targets white adipose tissue and skeletal muscle mitochondria

• Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice.preclinicalPMID 35013352 ↗
• NAD metabolism enzyme NNMT in cancer-associated fibroblasts drives tumor progression.mechanismPMID 39067875 ↗
• Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells.preclinicalPMID 33645410 ↗