Adamax

Adamax is a next-generation nootropic peptide and enhanced Semax analog featuring N-terminal acetylation and C-terminal adamantane modification for superior stability and blood-brain barrier penetration. It upregulates BDNF, enhances TrkB receptor sensitivity, modulates monoamines, and provides neuroprotection against oxidative stress and excitotoxicity.

• Upregulates BDNF (brain-derived neurotrophic factor) expression in hippocampus and cortex
• Enhances TrkB receptor sensitivity for improved neurotrophin signaling
• Modulates monoamine neurotransmitter levels (dopamine, norepinephrine, serotonin)
• Activates neuroprotective pathways reducing oxidative stress
• Stabilizes microtubules through ADNP-derived mechanisms
• Reduces excitotoxicity through neuromodulation

• unit: mcg

  low dose: 300

  frequency: daily

  high dose: 1000

  standard dose: 500

  administration route: Intranasal Spray

• unit: mcg

  low dose: 100

  frequency: daily

  high dose: 500

  standard dose: 300

  administration route: Subcutaneous Injection

• Can be used daily without cycling; however, some users rotate 5 days on / 2 days off to prevent tolerance development. Nasal mucosa health should be monitored during extended use.
• Daily administration recommended without cycling for cognitive support. Some protocols suggest 3 weeks on / 1 week off for tolerance management.

common: ["Nasal irritation or congestion (intranasal administration)","Mild headache (usually transient)","Slight insomnia if dosed late in the day"]

warnings: ["May cause anxiety or overstimulation at high doses","Risk of sleep disruption if taken in evening","Limited long-term human safety data available"]

long term: ["Long-term safety profile unknown in humans","Extrapolated from Semax clinical experience only"]

sequence: Ac-SEMAX-Adamantyl

half life: 2-4 hours (intranasal); 6-8 hours (subcutaneous)

degradation: Enzymatic degradation by serum proteases; slower degradation than native Semax due to adamantane modification.

molecular weight: 1568

molecular formula: C72H111N21O13

tissue specificity: CNS-specific distribution with high hippocampal, cortical, and striatal accumulation.