Argipressin

Argipressin (vasopressin) is a synthetic analog of antidiuretic hormone used in acute care to manage hypotension in vasodilatory shock and control excessive diuresis in diabetes insipidus. It acts on V1 and V2 receptors to regulate vascular tone and water reabsorption in the kidneys.

• Binds to V1 receptors on vascular smooth muscle to induce vasoconstriction
• Activates V2 receptors in renal collecting ducts, increasing aquaporin insertion and water reabsorption
• Restores arterial pressure by elevating systemic vascular resistance in shock
• Reduces free water clearance in the kidney without increasing sodium retention

• unit: units/min

  low dose: 0.01

  frequency: Continuous infusion

  high dose: 0.04

  standard dose: 0.03

  administration route: Intravenous (IV)

• Continuous infusion with titration between 0.01 to 0.04 units/min based on hemodynamic response. Monitoring is critical in ICU settings.

common: ["Hyponatremia","Abdominal cramps","Headache","Flushing"]

warnings: ["Can cause water intoxication and electrolyte imbalance if not monitored closely","Use cautiously in patients with coronary artery disease or chronic kidney disease"]

long term: ["May cause long-term changes in renal sodium handling if misused","Tachyphylaxis may develop in prolonged shock states"]

sequence: Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2

half life: 10 to 35 minutes

degradation: Rapid hepatic and renal enzymatic degradation

molecular weight: 1084.24

molecular formula: C46H65N15O12S2

tissue specificity: Targets vascular smooth muscle and renal collecting ducts

• Vasopressin and alcohol: a multifaceted relationship.reviewPMID 30392132 ↗
• Diabetes insipidus.reviewPMID 34718110 ↗