← Compounds
Berberine
supplement · adjunctOTCAMPK activation
Overview
Plant alkaloid; AMPK activator with glycemic and lipid effects. Community "natural metformin."
How it works
- AMPK activation
- ↓ hepatic glucose output
Dosing
500 mg 2–3× daily before meals.
Oral500 mg standard· 2–3x daily
Cycling
- Continuous
Side effects
- Common
- GI upset, cramping
- Warnings
- CYP interactions
Verified citations
2 · PubMed-checked- Therapeutic effect of berberine on metabolic diseases: pharmacological and clinical evidence.reviewPMID 33186794 ↗
- Berberine Phospholipid Is an Effective Insulin Sensitizer in Women with PCOS.clinicalPMID 34684666 ↗
Reconstitution
Not applicable — this compound is oral. No vial reconstitution needed.
Used for
No condition evidence rows yet.
Legal / compounding
OTC
- FDA
- Supplement (OTC)
Legal status is a hard gate: non-compoundable or delisted agents cannot be filled and are blocked from protocol export. Keep 503A status current.