Cardiogen

Cardiogen is a synthetic peptide shown to enhance cardiac regeneration, vascular perfusion, and myocardial bioenergetics. Originally developed to support heart recovery post-infarction, it is now studied for broader cardiometabolic and vascular applications in aging and disease. It acts by modulating endothelial and cardiac signaling at the cellular level.

• Stimulates cardiomyocyte regeneration and mitochondrial recovery
• Enhances angiogenesis via VEGF signaling in cardiac tissue
• Inhibits cardiac fibrosis by modulating TGF-β and inflammatory cytokines
• Improves endothelial function and nitric oxide (NO) production in vasculature

• unit: mcg

  low dose: 50

  frequency: Daily

  high dose: 150

  standard dose: 100

  administration route: Subcutaneous (SQ)

• unit: mcg

  low dose: 50

  frequency: Weekly

  high dose: 150

  standard dose: 100

  administration route: Intramuscular (IM)

• Administer daily for 4–8 weeks in cardiac recovery protocols. Pause for 2–4 weeks before restarting.
• Inject once weekly for 8 weeks. Typically used in chronic heart failure or post-MI rehabilitation cycles.

common: ["Mild fatigue, temporary blood pressure fluctuation (user-reported)","Minor stomach discomfort with oral form (user-reported)"]

sequence: AKGSPQKSDNKD

half life: Approximately 4 hours

degradation: Metabolized via hepatic and renal pathways

molecular weight: 1115.32

molecular formula: C50H74N16O15

tissue specificity: Selective for myocardium, vascular endothelium, and pericardial tissues

• The effect of the amino acids and cardiogen on the development of myocard tissue culture from young and old rats.preclinicalPMID 20210190 ↗
• Tumor-modifying effect of cardiogen peptide on M-1 sarcoma in senescent rats.preclinicalPMID 20396706 ↗