Cortagen

peptide · headlineResearch use only

Stimulates neurogenesis and axonal growth

Summary

Cortagen is a short synthetic tetrapeptide that exhibits neuroprotective and regenerative effects, particularly after injury. It has been shown to support cognitive function, nerve regrowth, and cardiovascular recovery. Used in protocols for TBI, aging, ischemia, and inflammatory neurodegeneration.

How it works

Stimulates neurogenesis and axonal growth
Enhances BDNF expression and synaptic plasticity
Reduces oxidative stress and inflammatory markers
May interact with mitochondrial repair pathways in neurons

Dosing

unit: mg
low dose: 0.05
frequency: Once daily
high dose: 0.2
standard dose: 0.1
administration route: Subcutaneous (SQ)

Cycling

Inject once daily for 10–20 days. Repeat every 3–6 months depending on neurological or cardiovascular recovery needs.

Side effects

Chemistry & PK

sequence: Ala-Gly-Gly-Lys

half life: 2–4 hours

degradation: Metabolized by peptidases and hepatic enzymes

molecular weight: 504.58

molecular formula: C24H36N6O6

tissue specificity: Targets neuronal and cardiac tissues under oxidative or structural stress

Verified citations

2 · PubMed-checked

Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart.mechanismPMID 15159690 ↗
Effect of tetrapeptide cortagen on regeneration of sciatic nerve.preclinicalPMID 11276314 ↗

Used for

No condition evidence rows yet.

Legal / compounding

Research use only

Legal status is a hard gate: non-compoundable or delisted agents cannot be filled and are blocked from protocol export. Keep 503A status current.