Cortexin

Cortexin is a peptide-based neurobioregulator derived from bovine brain extracts, widely used in Eastern Europe for cognitive decline, stroke recovery, and neurodevelopmental disorders. It exerts neuroprotective, metabolic, and anti-inflammatory effects, enhancing memory, learning, and synaptic repair.

• Modulates expression of neurotrophic factors such as BDNF and NGF
• Improves metabolic support for neurons by enhancing cerebral glucose and oxygen use
• Reduces excitotoxicity and regulates glutamate and GABA balance
• Exerts antioxidant and anti-inflammatory effects in the CNS

• unit: mg

  low dose: 5

  frequency: Once daily for 10 days per cycle

  high dose: 20

  standard dose: 10

  administration route: Intramuscular (IM)

• Inject 10 mg daily for 10 consecutive days. Repeat cycle every 3–6 months for chronic neurological support or cognitive maintenance.

common: ["Mild headache","Injection site irritation"]

warnings: ["May cause overstimulation or restlessness in sensitive individuals"]

long term: ["No significant adverse effects reported in existing clinical studies"]

sequence: Derived from polypeptide fractions of bovine cerebral cortex

half life: Not clearly defined; sustained biological activity observed

degradation: Hydrolyzed by tissue peptidases

molecular formula: Varied (Bioregulator Peptide Complex)

tissue specificity: High brain tissue specificity due to peptide fraction targeting

• Peptide drug cortexin inhibits brain caspase-8.mechanismPMID 28251948 ↗
• An open clinical trial of cortexin in treatment of brain ischemia.clinicalPMID 25403301 ↗
• Cortexin. Molecular mechanisms and targets of neuroprotective activity.reviewPMID 26356623 ↗