DSIP (Delta Sleep-Inducing Peptide)

DSIP (Delta Sleep-Inducing Peptide) is a short neuropeptide with documented ability to promote deep sleep, reduce stress, and modulate circadian rhythms. Often used to support recovery, anxiety reduction, and HPA balance, DSIP has broad experimental interest for its neuroendocrine effects.

• Modulates delta sleep EEG activity via hypothalamic pathways
• Inhibits corticotropin-releasing hormone (CRH), reducing stress
• Stabilizes neuronal excitability and acts as a mild neuropeptide anxiolytic
• May influence melatonin, serotonin, and other neuroendocrine rhythms

• unit: mcg

  low dose: 100

  frequency: 30–60 minutes before bedtime

  high dose: 400

  standard dose: 200

  administration route: Subcutaneous (SQ)

• Use nightly for 2–4 weeks, then cycle off for 1–2 weeks to prevent receptor fatigue. Take 30–60 minutes before bed.

common: ["Morning fatigue/lethargy if dose too high or wrong timing","Headache, dizziness, nausea","Stomach pain/GI issues"]

warnings: ["May interact with GABA/NMDA receptor activity; risk with sedatives and alcohol"]

long term: ["Long-term safety not established; not FDA-approved"]

sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

half life: 15–30 minutes systemically; longer CNS effect suspected

degradation: Primarily metabolized by peptidases and hepatic clearance

molecular weight: 848.8

molecular formula: C35H48N10O15

tissue specificity: Acts on hypothalamus, pineal gland, hippocampus, and reticular formation

• The influence of synthetic DSIP on disturbed human sleep.clinicalPMID 7028502 ↗
• The effects of DSIP on wakefulness and sleep patterns in the cat.preclinicalPMID 3620931 ↗
• Delta sleep-inducing peptide (DSIP): a still unresolved riddle.reviewPMID 16539679 ↗