← Compounds
Estradiol
hormone · comparatorFDA-approvedEstrogen receptor agonism
Overview
Estrogen replacement — the backbone of menopausal HRT. Transdermal preferred (lower VTE risk).
How it works
- Estrogen receptor agonism
Dosing
Transdermal 0.025–0.1 mg/day, or oral; individualized.
Transdermal0.05 mg/day standard· patch 1–2x weekly
Cycling
- Continuous
Side effects
- Common
- Breast tenderness
- Bloating
- Unscheduled bleeding
- Warnings
- VTE risk (oral > transdermal); needs progesterone if uterus intact
Verified citations
2 · PubMed-checked- Tailoring transdermal estradiol dose to maximize benefits and minimize risks.reviewPMID 41529140 ↗
- Menopausal Hormone Therapy and Cardiovascular Disease: Role of Formulation, Dose, and Route.reviewPMID 33506261 ↗
Reconstitution
Not applicable — this compound is transdermal. No vial reconstitution needed.
Legal / compounding
FDA-approved
- FDA
- Approved
Legal status is a hard gate: non-compoundable or delisted agents cannot be filled and are blocked from protocol export. Keep 503A status current.