GHRP-6

GHRP-6 is a growth hormone-releasing hexapeptide that mimics ghrelin to stimulate the pituitary gland. It is studied in both preclinical and clinical settings for its GH-promoting and appetite-stimulating properties; commonly stacked with CJC-1295 for synergistic GH release.

• Activates ghrelin receptor (GHS-R1a)
• Stimulates release of growth hormone from the anterior pituitary
• Enhances appetite and anabolic signaling via GH axis

• unit: mcg

  low dose: 100

  frequency: Up to twice daily

  high dose: 300

  standard dose: 200

  administration route: Subcutaneous (SQ)

• unit: mcg

  low dose: 20

  frequency: Up to twice daily

  high dose: 50

  standard dose: 30

  administration route: Intranasal

• Use 8–12 weeks followed by 4-week break. Administer before meals or at night to optimize GH secretion.
• Administer 1–2x daily with enhanced intranasal formulation. Use same cycling strategy as injection.

common: ["Transient ACTH and cortisol elevation post-injection (clinically insignificant) (human trial)"]

sequence: His-D-Trp-Ala-Trp-D-Phe-Lys-NH2

half life: Approximately 30 minutes

degradation: Metabolized in liver and kidneys

molecular weight: 873.01

molecular formula: C46H56N12O6

tissue specificity: Acts on GH receptor pathways, muscle, and adipose tissue

• GHRP-6 acts as a survival factor in glutamate-induced excitotoxicity.mechanismPMID 17076656 ↗
• Use of GHRP-6 for the prevention of multiple organ failure.preclinicalPMID 16417467 ↗