← Compounds
Ketotifen
on-label Rx · comparatorFDA-approvedMast-cell stabilization + H1 antagonism
Overview
Mast-cell stabilizer and H1 antihistamine; common MCAS adjunct.
How it works
- Mast-cell stabilization
- H1 antagonism
Dosing
1–2 mg PO twice daily (often compounded in the US).
Oral2 mg standard· BID
Cycling
- Continuous
Side effects
- Common
- Sedation
- Weight gain
- Warnings
Verified citations
2 · PubMed-checked- Ketotifen. A review of its pharmacodynamic and pharmacokinetic properties and use in allergic disorders.reviewPMID 2226222 ↗
- Ketotifen is a Prodrug. Norketotifen is the active metabolite.mechanismPMID 34410005 ↗
Reconstitution
Not applicable — this compound is oral. No vial reconstitution needed.
Used for
No condition evidence rows yet.
Legal / compounding
FDA-approved
- FDA
- Approved (ophthalmic); oral often compounded in US
Legal status is a hard gate: non-compoundable or delisted agents cannot be filled and are blocked from protocol export. Keep 503A status current.