← Compounds
Levothyroxine
on-label Rx · comparatorFDA-approvedThyroid hormone replacement (T4)
Overview
Synthetic T4 — the backbone of Hashimotos/hypothyroid management. Peptides are layered on top, never in place of it.
How it works
- Thyroid hormone replacement (T4→T3)
Dosing
~1.6 mcg/kg/day, taken fasting; titrate to TSH.
Oral100 mcg standard· daily, fasting
Cycling
- Continuous, lifelong
Side effects
- Common
- (Over-replacement) palpitations, anxiety
- Warnings
- Over-replacement → bone/cardiac risk
Verified citations
2 · PubMed-checked- Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Combination in Hypothyroidism.clinicalPMID 34185829 ↗
- Treating hypothyroidism: subclinical hypothyroidism, TSH goals, alternatives to levothyroxine.reviewPMID 34766382 ↗
Reconstitution
Not applicable — this compound is oral. No vial reconstitution needed.
Used for
No condition evidence rows yet.
Legal / compounding
FDA-approved
- FDA
- Approved
Legal status is a hard gate: non-compoundable or delisted agents cannot be filled and are blocked from protocol export. Keep 503A status current.