Melanotan II

Melanotan II is a synthetic melanocortin peptide that increases melanin production and stimulates sexual arousal. It binds MC1R for tanning and MC4R for libido enhancement, and has been studied for its effects on skin pigmentation and sexual arousal in preclinical models and limited human trials. Unlike MT-1, it has central nervous system activity.

• Non-selectively binds to melanocortin receptors (MC1R, MC3R, MC4R)
• Stimulates melanin synthesis in melanocytes for skin darkening
• Activates central arousal pathways through MC4R in hypothalamus
• May modulate appetite and fat metabolism through MC3R

• unit: mg

  low dose: 0.25

  frequency: As needed or daily during tanning phase

  high dose: 1

  standard dose: 0.5

  administration route: Subcutaneous (SQ)

• Inject 0.25–0.5 mg daily for 10–14 days for tanning phase. For sexual effects, use 0.5–1 mg as needed. Do not exceed 1 mg/day without guidance.

common: ["Nausea (dose-dependent, most common at higher doses)","Facial flushing, increased skin warmth","Reduced appetite and mild fatigue","Spontaneous erections and increased libido in men","Transient HR and BP increases at higher doses"]

warnings: ["Not FDA-approved; use carries regulatory and safety risks","Severe toxicity at 6 mg dose (rhabdomyolysis reported)","May alter mole pigmentation; case reports of melanoma — theoretical melanoma concerns"]

sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

half life: 33–38 minutes

degradation: Cleared by liver and kidneys

molecular weight: 1025.2

molecular formula: C50H69N15O9

tissue specificity: Melanocytes, hypothalamus, and CNS sexual centers

• CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists.mechanismPMID 35188390 ↗
• Melanotan II User Experience: A Qualitative Study of Online Discussion Forums.clinicalPMID 34464955 ↗