Metformin

off-label Rx · medium oversightFDA-approved

AMPK activation; reduced hepatic gluconeogenesis

Summary

Biguanide; first-line for insulin resistance in PCOS and widely used off-label for longevity. Activates AMPK and reduces hepatic gluconeogenesis.

How it works

AMPK activation
↓ hepatic gluconeogenesis
↑ insulin sensitivity

Dosing

unit: mg
frequency: daily (ER, with food)
high dose: 2000
standard dose: 1000
administration route: Oral

Cycling

Continuous

Side effects

common: ["GI upset (dose-related)","B12 depletion (long-term)"]

warnings: ["Rare lactic acidosis (renal impairment)"]

Verified citations

2 · PubMed-checked

Metformin improves healthspan and lifespan in mice.preclinicalPMID 23900241 ↗
Evidence That Metformin Is a Putative Anti-Aging Drug.reviewPMID 34421827 ↗

Used for

Legal / compounding

FDA-approved

Legal status is a hard gate: non-compoundable or delisted agents cannot be filled and are blocked from protocol export. Keep 503A status current.