PAL-GHK

PAL-GHK is a lipopeptide derivative of the GHK sequence used in skin rejuvenation. It improves collagen synthesis, reduces signs of aging, and promotes epidermal repair. PAL-GHK is commonly found in cosmetic serums and creams for daily use to restore youthful skin structure and reduce inflammation.

• Enhances extracellular matrix (ECM) activity by stimulating fibroblasts
• Upregulates genes associated with skin regeneration and repair
• Suppresses pro-inflammatory cytokines and oxidative enzymes
• Promotes angiogenesis and glycosaminoglycan (GAG) synthesis

• unit: %

  low dose: 0.5

  frequency: Once or twice daily

  high dose: 2

  standard dose: 1

  administration route: Topical

• Apply once or twice daily. Continuous use for 8–12 weeks recommended for optimal cosmetic benefit. Maintenance use can follow at 1x daily.

common: ["Mild irritation or redness at application site","Temporary dryness or tingling"]

warnings: ["Patch test recommended before use in individuals with sensitive skin or rosacea"]

long term: ["Well tolerated in long-term cosmetic use; no systemic adverse effects reported"]

sequence: Palmitoyl-Gly-His-Lys

half life: Not clearly defined in topical use

degradation: Metabolized locally by skin enzymes

molecular weight: 578

molecular formula: C30H54N6O9

tissue specificity: Targets dermis and epidermis for skin regeneration and anti-aging

• Topically applied GHK as an anti-wrinkle peptide.reviewPMID 39963574 ↗