PEG MGF

PEG MGF is a PEGylated variant of Mechano Growth Factor, a splice form of IGF-1 expressed in muscle post-exercise. PEGylation significantly prolongs its half-life, making it more effective for sustained muscle repair and hypertrophy. It has been studied for its role in muscle recovery and hypertrophy in rodent models.

• PEGylation extends duration of action by reducing renal clearance
• Stimulates muscle satellite cells to promote regeneration
• Mimics localized IGF-1 splicing in response to mechanical loading

• unit: mcg

  low dose: 100

  frequency: 2-3 times a week

  high dose: 400

  standard dose: 200

  administration route: Subcutaneous (SQ)

• Administer 2–3x per week, post-exercise. Typical cycle duration is 6–12 weeks followed by an equal off-cycle to avoid receptor fatigue or resistance.

common: ["Localized irritation or swelling at injection site"]

warnings: ["Risk of immune sensitization with repeated long-term use","Should not be used in individuals with active malignancies"]

long term: ["Limited long-term safety data in humans"]

sequence: PEGylated IGF-1 Ec variant

half life: 2–3 days with PEGylation

degradation: Resists enzymatic breakdown due to PEG coating

molecular weight: 2867.36

molecular formula: C121H200N42O39

tissue specificity: Targets skeletal muscle tissue and repair sites

• The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis.reviewPMID 42395176 ↗