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Pinealon

peptide · headlineResearch use only

Crosses the blood-brain barrier and enhances neural gene expression

Summary

Pinealon is a synthetic tripeptide bioregulator derived from pineal and brain tissue that promotes neuroprotection, memory consolidation, and pineal gland function. It is used in aging, cognitive decline, and circadian rhythm regulation protocols and has demonstrated antioxidant and geroprotective properties in preclinical studies.

How it works

  • Crosses the blood-brain barrier and enhances neural gene expression
  • Supports pineal gland-mediated hormonal balance (e.g., melatonin)
  • Increases resistance of neurons to oxidative stress and metabolic damage
  • Stabilizes bioelectrical activity in cerebral cortex and hippocampus

Dosing

  • unit: mcg
    low dose: 3
    frequency: Daily
    high dose: 10
    standard dose: 5
    administration route: Subcutaneous (SQ)

Cycling

  • Administer daily for 10–20 days. Repeat every 4–6 months for cognitive maintenance or aging support.

Side effects

common: ["Headaches (tension-like)","Vivid dreams/insomnia if taken late","Mild anxiety, dizziness, nausea","Changes in bowel habits"]

Chemistry & PK

sequence: Lys-Gly-Asn
half life: Approximately 20 minutes
degradation: Metabolized by tissue peptidases and liver enzymes
molecular weight: 200.25
molecular formula: C10H16N2O3
tissue specificity: Targets pineal gland, hippocampus, and neocortex

Verified citations

2 · PubMed-checked
  • Effect of synthetic peptides on aging of patients with organic brain syndrome.clinicalPMID 26390612
  • EDR Peptide: Mechanism of Gene Expression Regulation in Alzheimer's Disease.mechanismPMID 33396470

Used for

No condition evidence rows yet.

Legal / compounding

Research use only

Legal status is a hard gate: non-compoundable or delisted agents cannot be filled and are blocked from protocol export. Keep 503A status current.