Semax

Semax is a synthetic ACTH-derived neuropeptide used for its cognitive-enhancing, neuroprotective, and antidepressant effects. Developed in Russia, it modulates neurotransmitters and neurotrophic factors like BDNF. It is used in cognitive decline, stress recovery, stroke rehabilitation, and neuropsychiatric disorders in both animal models and limited human trials.

• Modulates neurotransmitter levels by increasing dopamine and serotonin availability
• Upregulates BDNF (brain-derived neurotrophic factor), enhancing synaptic plasticity
• Exerts antioxidant effects, reducing oxidative stress and neuroinflammation
• Influences melanocortin receptors involved in cognition, emotion, and immune modulation

• unit: mg

  low dose: 0.05

  frequency: 2-3 times daily

  high dose: 0.2

  standard dose: 0.1

  administration route: Intranasal

• Used 2–3 times daily for 10–14 days. Repeat cycles every 1–3 months based on cognitive or stress recovery goals.

common: ["Headache, restlessness, slight BP fluctuations"]

sequence: Met-Glu-His-Phe-Pro-Gly-Pro

half life: Likely short (minutes in plasma); CNS effects persist longer due to gene regulation

degradation: Metabolized by tissue peptidases

molecular weight: 813.93

molecular formula: C37H51N9O10S

tissue specificity: Primarily acts in the brain: hippocampus, cortex, hypothalamus

• Semax peptide targets the mu opioid receptor gene to promote recovery after spinal cord injury.mechanismPMID 40692165 ↗
• The peptide semax affects immune and vascular gene expression in rat brain focal ischemia.preclinicalPMID 24661604 ↗