Spironolactone

on-label Rx · comparatorFDA-approved

Androgen receptor + aldosterone antagonism

Overview

Aldosterone antagonist with anti-androgen activity; standard for PCOS hirsutism.

How it works

Androgen receptor antagonism
Aldosterone antagonism

Dosing

50–200 mg/day for hirsutism.

Oral100 mg standardrange —–200 mg· daily

Cycling

Continuous

Side effects

Common: Menstrual irregularity
Breast tenderness
Warnings: Hyperkalemia — monitor K+

Verified citations

2 · PubMed-checked

The spironolactone renaissance.reviewPMID 11322868 ↗
Spironolactone for Acne: Practical Strategies for Optimal Clinical Outcomes.reviewPMID 40875941 ↗

Reconstitution

Not applicable — this compound is oral. No vial reconstitution needed.

Used for

Legal / compounding

FDA-approved

FDA: Approved

Legal status is a hard gate: non-compoundable or delisted agents cannot be filled and are blocked from protocol export. Keep 503A status current.