Spironolactone

on-label Rx · comparatorFDA-approved

Androgen receptor + aldosterone antagonism

Summary

Aldosterone antagonist with anti-androgen activity; standard for PCOS hirsutism.

How it works

Androgen receptor antagonism
Aldosterone antagonism

Dosing

unit: mg
frequency: daily
high dose: 200
standard dose: 100
administration route: Oral

Cycling

Continuous

Side effects

common: ["Menstrual irregularity","Breast tenderness"]

warnings: ["Hyperkalemia — monitor K+"]

Verified citations

2 · PubMed-checked

The spironolactone renaissance.reviewPMID 11322868 ↗
Spironolactone for Acne: Practical Strategies for Optimal Clinical Outcomes.reviewPMID 40875941 ↗

Used for

Legal / compounding

FDA-approved

Legal status is a hard gate: non-compoundable or delisted agents cannot be filled and are blocked from protocol export. Keep 503A status current.