Chronic fatigue / burnout
Bioenergetic failure with immune & HPA overlap; restore mitochondrial output.
Decision support, not prescription. You decide.
Warning — BPC-157 crash risk in post-viral/ME-CFS
Post-viral/ME-CFS patients report crashing at standard dose; microdose 10–25%.
Candidate agents
5 agents · ranked by role, then evidenceIn CFS, oral NADH combined with CoQ10 reduced perceived fatigue and fatigue-impact scores in two small 8-week RCTs, and raised intracellular NAD+/NADH and ATP; evidence is for the NADH+CoQ10 combination, not NAD+ monotherapy.
PMID 25386668In the phase 3 MMPOWER-3 RCT in primary mitochondrial myopathy, subcutaneous elamipretide did NOT improve total fatigue score or 6-minute walk distance vs placebo (Class I evidence), though it was well tolerated.
PMID 37268435MOTS-c, a 16-aa mitochondrial-derived peptide, activates AMPK in skeletal muscle and improved insulin sensitivity and metabolic homeostasis in mice; proposed as an exercise mimetic, but evidence in fatigue/burnout is entirely preclinical.
PMID 25738459Humanin is a mitochondrial-derived cytoprotective peptide of interest for bioenergetic decline, but there is no direct human or animal literature evaluating it in chronic fatigue or burnout; listed as a mechanistic gap, not an evidence-backed option.
Low-dose naltrexone (typically 4.5 mg/day) has reported symptom benefit in a small ME/CFS case series and in related fibromyalgia/post-COVID fatigue, with a favorable safety profile; a phase II RCT for post-COVID fatigue is underway but confirmatory controlled efficacy data are lacking (evidence to date is case-series/anecdotal plus an unfinished protocol).
PMID 31911410Matching protocol templates
Browse all →Metabolic enhancement, NAD+ support, mitochondrial function
Fat loss, cellular energy enhancement, metabolic reset
Post-viral recovery, metabolic reset, endurance support
The platform surfaces evidence, community signal and peer outcomes with enforced cautions. It never decides treatment — the licensed clinician orders labs, writes notes, and prescribes.