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Cortexin
Neuroprotective & Cognitive EnhancersCortexin is a peptide-based neurobioregulator derived from bovine brain extracts, widely used in Eastern Europe for cognitive decline, stroke recovery, and neurodevelopmental disorders. It exerts neuroprotective, metabolic, and anti-inflammatory effects, enhancing memory, learning, and synaptic repair.
Reconstitute
2 mL BAC + 10mg vial
50 mcg/unit
Daily Range
5–20 mg Intramuscular (IM)
Once daily for 10 days per cycle
Standard Dose
10 mg
Cycle
4–8 weeks
then reassess
Cortexinneuroprotective peptidestroke recoverycognitive enhancementBDNF
Dosing & Reconstitution Guide
Standard dose is 10mg intramuscularly or intravenously daily for 10 days. Do not exceed recommended dosing. Potential side effects may include mild injection site reactions.
Standard / Gradual Approach
10mg VialstandardPhaseDoseVolume
Days 1-510mg
Days 6-1010mg
After Day 10Rest period
Protocol Summary
Intramuscular (IM): Once daily for 10 days per cycle · Dose range 5–20 mg with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending
Frequency & Cycling
IM Injection
Inject 10 mg daily for 10 consecutive days. Repeat cycle every 3–6 months for chronic neurological support or cognitive maintenance.
🧪 Quick Start
Vial Size
10 mg
BAC Water
2 mL
Concentration
5000 mcg/unit
Potential Benefits & Use Cases
Cortexin is not approved by the FDA for use in the United States. It is approved in some European and Asian countries. Use only for approved research purposes.
Neuroprotective effects
Enhances memory and learning
Reduces neuroinflammation
Supports synaptic plasticity and regeneration
Clinical data Strong preclinical Limited data
Mechanism of Action
→Modulates expression of neurotrophic factors such as BDNF and NGF
→Improves metabolic support for neurons by enhancing cerebral glucose and oxygen use
→Reduces excitotoxicity and regulates glutamate and GABA balance
→Exerts antioxidant and anti-inflammatory effects in the CNS
Lifestyle & Optimization
timing
Morning administration for cognitive benefits throughout the day.
diet
Brain-healthy diet rich in omega-3 fatty acids.
exercise
Regular exercise 3–4 times per week for improved cerebral blood flow. Engage in mental exercises.
sleep
Adequate sleep (7–9 hours nightly) supports cognitive function.
Peptide Research & Preclinical Studies
Evidence-Based Research Findings
Study TitleType
Side Effects & Safety
Common Side Effects
• Mild headache
• Injection site irritation
Contraindications & Warnings
• May cause overstimulation or restlessness in sensitive individuals
Long-Term Safety Data
• No significant adverse effects reported in existing clinical studies
🧮 Dose Calculator
Concentration
50.0
mcg/unit
Draw Volume
10
units (0.100 mL)
For a 500 mcg dose, draw 10 units on a U-100 insulin syringe
🧬
Bioavailability & Absorption
SubQ Injection
Not typically used
Oral Administration
Not applicable
Intranasal
Not applicable
Half-Life
Not clearly defined; sustained biological activity observed
Degradation
Hydrolyzed by tissue peptidases
Tissue Specificity
High brain tissue specificity due to peptide fraction targeting
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Peptide Details
Molecular Weight
Formula
Varied (Bioregulator Peptide Complex)
Sequence
Derived from polypeptide fractions of bovine cerebral cortex
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Legal Status & Regulatory
RegionStatus
FDANot Approved
EUApproved
AustraliaNot Approved
CanadaNot Approved
Storage Instructions
Lyophilized (Powder)
Store lyophilized powder at 2-8°C or room temperature (check supplier guidance)
Reconstituted (Mixed)
After reconstitution, use immediately or store at 2-8°C for up to 24 hours. Best used fresh.