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Dihexa

Neuroprotective & Cognitive Enhancers

Dihexa is a synthetic neurogenic peptide that enhances cognitive performance and brain plasticity through HGF/c-Met activation. It promotes memory formation, synaptic repair, and long-term potentiation, and is under investigation for Alzheimer's, stroke recovery, and neurodegeneration.

Reconstitute
3 mL BAC + 500mg vial
1667 mcg/unit
Daily Range
2–10 mg Oral
Once daily
Standard Dose
5 mg
Cycle
4–8 weeks
then reassess
Dihexaneurogenic peptidecognitive enhancementHGF/c-Metnootropic

Dosing & Reconstitution Guide

Rodent research has used oral doses ranging from 1–10 mg/kg. These findings are experimental and not validated in humans.

Standard / Gradual Approach

0standard
PhaseDoseVolume
Weeks 1–22 mg oral daily1 capsule
Weeks 3–45 mg oral daily1 capsule
Weeks 5–125–10 mg oral daily1–2 capsules

Protocol Summary

Oral: Once daily · Dose range 2–10 mg with gradual titration
Topical: Apply 1–2x daily · Dose range 0.5–2 % with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending

Frequency & Cycling

Oral

Use once daily for 8–12 weeks. Monitor for cognitive benefit and cycle off 2–4 weeks between blocks.

Topical

Apply 1–2x daily to temples or back of neck for localized neurodermal delivery. Follow same cycle as oral use.

🧪 Quick Start

Starting Dose
2 mg

Potential Benefits & Use Cases

Dihexa is not FDA-approved and should only be used in laboratory research settings.
Enhances synapse formation in vitro
Improves memory in Alzheimer’s models (rodents)
Binds to HGF/c-Met receptor to promote neuroplasticity
Studied for recovery of cognitive function in aging models
Non-toxic in preclinical toxicology studies
Clinical data Strong preclinical Limited data

Mechanism of Action

→Activates hepatocyte growth factor (HGF)/c-Met signaling to enhance neurogenesis
→Promotes synaptic connectivity and dendritic branching
→Elevates brain-derived neurotrophic factor (BDNF)
→Mimics angiotensin IV action in CNS

Lifestyle & Optimization

timing

Consistent daily dosing. Oral or SubQ.

diet

Diet rich in choline sources (eggs, fish). Combine with neurotrophic support: lion's mane, phosphatidylserine, or bacopa.

exercise

Regular exercise. Practice spaced repetition learning to leverage enhanced synaptogenesis.

sleep

Consistent sleep schedule (7–9 hours).

Peptide Research & Preclinical Studies

Evidence-Based Research Findings

Study TitleType
Dihexa: A novel cognitive enhancer derived from angiotensin IVPreclinical
Angiotensin IV analogs for cognitive enhancementReview
HGF/Met activation and synapse formation via DihexaPreclinical

Side Effects & Safety

Common Side Effects

• Headache
• Mild nausea
• Occasional restlessness or stimulation

Contraindications & Warnings

• Potential overstimulation of HGF/c-Met pathway could raise tumorigenic risk in predisposed individuals
• Avoid use with active cancers

Long-Term Safety Data

• Long-term safety in humans is unknown; preclinical trials suggest neurogenic persistence

🧮 Dose Calculator

Concentration
1666.7
mcg/unit
Draw Volume
—
units (0.000 mL)
For a 500 mcg dose, draw 0 units on a U-100 insulin syringe
🧬

Bioavailability & Absorption

Oral Administration
Moderate; designed for systemic brain penetration
Half-Life
Not precisely defined; effects persist due to synaptic changes
Degradation
Liver metabolism; avoids first-pass peptide degradation
Tissue Specificity
Central nervous system: cortex, hippocampus, limbic structures
⚗️

Peptide Details

Molecular Weight
738.9
Formula
C39H62N8O6
Sequence
Hexanoyl-Tyr-Ile-Ahx-NH2
⚖️

Legal Status & Regulatory

RegionStatus
FDANot Approved
EUNot Approved
AustraliaNot Approved
CanadaNot Approved

Storage Instructions

Lyophilized (Powder)
Store capsules at room temperature (15–25°C) in a cool, dry place. Protect from moisture and light.
Reconstituted (Mixed)
Topical cream: store at room temperature. Use within 3 months of compounding.