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DSIP (Delta Sleep-Inducing Peptide)
Neuroprotective & Cognitive EnhancersDSIP (Delta Sleep-Inducing Peptide) is a short neuropeptide with documented ability to promote deep sleep, reduce stress, and modulate circadian rhythms. Often used to support recovery, anxiety reduction, and HPA balance, DSIP has broad experimental interest for its neuroendocrine effects.
Reconstitute
3 mL BAC + 5mg vial
17 mcg/unit
Daily Range
100–400 mcg Subcutaneous (SQ)
30–60 minutes before bedtime
Standard Dose
200 mcg
Cycle
4–8 weeks
then reassess
DSIPdelta sleep peptidesleep optimizationanxiolytic peptideHPA regulation
Dosing & Reconstitution Guide
In rodent studies, DSIP was used at 100–500 μg/kg IP or IV. Human effects are not well characterized. Not approved for sleep therapy or clinical use.
Standard / Gradual Approach
5mg VialstandardPhaseDoseVolume
Week 1100 mcg6 units (0.06 mL)
Week 2150 mcg9 units (0.09 mL)
Week 3200 mcg12 units (0.12 mL)
Weeks 4–8250–300 mcg15–18 units (0.15–0.18 mL)
Standard / Gradual Approach
5mg VialadvancedPhaseDoseVolume
Week 5350–400 mcg21–24 units (0.21–0.24 mL)
Weeks 6–8+400–500 mcg24–30 units (0.24–0.30 mL)
Standard / Gradual Approach
10mg VialstandardPhaseDoseVolume
Week 1100 mcg3 units (0.03 mL)
Week 2150 mcg5 units (0.05 mL)
Week 3200 mcg6 units (0.06 mL)
Weeks 4–8250–300 mcg8–9 units (0.08–0.09 mL)
Protocol Summary
Subcutaneous (SQ): 30–60 minutes before bedtime · Dose range 100–400 mcg with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending
Frequency & Cycling
SubQ Injection
Use nightly for 2–4 weeks, then cycle off for 1–2 weeks to prevent receptor fatigue. Take 30–60 minutes before bed.
🧪 Quick Start
Vial Size
5 mg
BAC Water
3 mL
Concentration
1.67 mcg/unit
Starting Dose
100 mcg before bedtime
Maintenance Dose
100 mcg nightly
Potential Benefits & Use Cases
DSIP is a research-use-only peptide. It is not approved for sleep support or therapeutic use in any country.
Promotes deeper, more restorative slow-wave sleep and improves subjective sleep quality (limited human data)
Demonstrates stress-protective and anxiolytic-like effects (preclinical)
Does not appear to induce pharmacological tolerance with continued use (limited human data)
Supports immune cell proliferation and tumor growth reduction in animal models (preclinical)
Clinical data Strong preclinical Limited data
Mechanism of Action
→Modulates delta sleep EEG activity via hypothalamic pathways
→Inhibits corticotropin-releasing hormone (CRH), reducing stress
→Stabilizes neuronal excitability and acts as a mild neuropeptide anxiolytic
→May influence melatonin, serotonin, and other neuroendocrine rhythms
Lifestyle & Optimization
timing
Administer at bedtime for sleep induction.
diet
Limit stimulants (caffeine) before bed.
exercise
Regular exercise earlier in the day — not close to bedtime.
sleep
Consistent sleep-wake schedules. Cool, dark, quiet environment. Limit blue light before bed. Stress management.
Peptide Research & Preclinical Studies
Evidence-Based Research Findings
Study TitleType
PMC — Stress hormones and DSIPReference
Side Effects & Safety
Common Side Effects
• Morning fatigue/lethargy if dose too high or wrong timing
• Headache, dizziness, nausea
• Stomach pain/GI issues
Contraindications & Warnings
• May interact with GABA/NMDA receptor activity; risk with sedatives and alcohol
Long-Term Safety Data
• Long-term safety not established; not FDA-approved
🧮 Dose Calculator
Concentration
16.7
mcg/unit
Draw Volume
30
units (0.300 mL)
For a 500 mcg dose, draw 30 units on a U-100 insulin syringe
🧬
Bioavailability & Absorption
SubQ Injection
High absorption and CNS penetration observed in animal models
Oral Administration
Not viable due to rapid degradation
Half-Life
15–30 minutes systemically; longer CNS effect suspected
Degradation
Primarily metabolized by peptidases and hepatic clearance
Tissue Specificity
Acts on hypothalamus, pineal gland, hippocampus, and reticular formation
⚗️
Peptide Details
Molecular Weight
848.8
Formula
C35H48N10O15
Sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
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Legal Status & Regulatory
RegionStatus
FDANot Approved
EUNot Approved
AustraliaNot Approved
CanadaNot Approved
Storage Instructions
Lyophilized (Powder)
Store lyophilized powder at -20°C for long-term or 2-8°C for up to 6 months. Protect from light and moisture. Do not freeze reconstituted solution. Avoid repeated temperature fluctuations.
Reconstituted (Mixed)
Refrigerate at 2-8°C. Use within 3-4 weeks.