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GHRP-6
Growth Factors & Muscle BuildingGHRP-6 is a growth hormone-releasing hexapeptide that mimics ghrelin to stimulate the pituitary gland. It is studied in both preclinical and clinical settings for its GH-promoting and appetite-stimulating properties; commonly stacked with CJC-1295 for synergistic GH release.
Reconstitute
2.5 mL BAC + 5mg vial
20 mcg/unit
Daily Range
100–300 mcg Subcutaneous (SQ)
Up to twice daily
Standard Dose
200 mcg
Cycle
4–8 weeks
then reassess
GHRP-6Growth HormoneGhrelin receptorBody compositionSecretagogue
Dosing & Reconstitution Guide
In clinical research, doses range from 100–300 μg per injection, typically 2–3x daily. These are investigational values and not approved for therapeutic use.
Standard / Gradual Approach
2mg VialstandardPhaseDoseVolume
Weeks 1–2100 mcg15 units (0.15 mL)
Weeks 3–4200 mcg30 units (0.30 mL)
Weeks 5–12300 mcg45 units (0.45 mL)
Standard / Gradual Approach
10mg VialstandardPhaseDoseVolume
Weeks 1–2100 mcg3 units (0.03 mL)
Weeks 3–4200 mcg6 units (0.06 mL)
Weeks 5–12300 mcg9 units (0.09 mL)
Protocol Summary
Subcutaneous (SQ): Up to twice daily · Dose range 100–300 mcg with gradual titration
Intranasal: Up to twice daily · Dose range 20–50 mcg with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending
Frequency & Cycling
SubQ Injection
Use 8–12 weeks followed by 4-week break. Administer before meals or at night to optimize GH secretion.
Intranasal
Administer 1–2x daily with enhanced intranasal formulation. Use same cycling strategy as injection.
🧪 Quick Start
Vial Size
5 mg
BAC Water
3 mL
Concentration
2 mcg/unit
Potential Benefits & Use Cases
GHRP-6 is a research compound not approved by the FDA or any regulatory body for medical use.
Produces consistent GH and IGF-1 elevation supporting anabolic processes (human trial)
May enhance lean muscle mass, strength, and tissue repair through IGF-1 elevation (preclinical)
Pronounced ghrelin-mimetic appetite stimulation within 20–30 minutes post-injection — useful for cachexia (human trial)
Increases stage 2 sleep duration (270 minutes vs 245 minutes placebo) without major REM disruption (human trial)
Clinical data Strong preclinical Limited data
Mechanism of Action
→Activates ghrelin receptor (GHS-R1a)
→Stimulates release of growth hormone from the anterior pituitary
→Enhances appetite and anabolic signaling via GH axis
Lifestyle & Optimization
timing
Administer on empty stomach (2–3 hours post-meal). GH peaks during deep sleep.
diet
Protein-forward diet. Mind appetite stimulation if fat loss is the goal.
exercise
Resistance and aerobic training.
sleep
Prioritize sleep — GH peaks during deep sleep.
Peptide Research & Preclinical Studies
Evidence-Based Research Findings
Study TitleType
Side Effects & Safety
Common Side Effects
• Transient ACTH and cortisol elevation post-injection (clinically insignificant) (human trial)
🧮 Dose Calculator
Concentration
20.0
mcg/unit
Draw Volume
25
units (0.250 mL)
For a 500 mcg dose, draw 25 units on a U-100 insulin syringe
🧬
Bioavailability & Absorption
SubQ Injection
High systemic bioavailability via subcutaneous injection
Oral Administration
Poor oral bioavailability
Intranasal
Moderate with enhanced delivery carriers
Half-Life
Approximately 30 minutes
Degradation
Metabolized in liver and kidneys
Tissue Specificity
Acts on GH receptor pathways, muscle, and adipose tissue
⚗️
Peptide Details
Molecular Weight
873.01
Formula
C46H56N12O6
Sequence
His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
⚖️
Legal Status & Regulatory
RegionStatus
FDANot Approved
EUNot Approved
AustraliaNot Approved
CanadaNot Approved
Storage Instructions
Lyophilized (Powder)
freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles
Reconstituted (Mixed)
Refrigerate at 2–8 °C (35.6–46.4 °F); use within 28 days with bacteriostatic water