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Hexarelin

Growth Factors & Muscle Building

Hexarelin is a potent growth hormone secretagogue peptide that stimulates GH release via ghrelin receptor binding. It is studied in animal models and human research for its robust GH stimulation and potential cardiovascular effects. Although effective, long-term continuous use may lead to GH axis desensitization.

Reconstitute
2 mL BAC + 2mg vial
10 mcg/unit
Daily Range
0.5–2 mcg Subcutaneous (SQ)
Daily
Standard Dose
1 mcg
Cycle
4–8 weeks
then reassess
HexarelinGrowth HormoneSecretagogueMuscle GrowthGhrelin agonist

Dosing & Reconstitution Guide

Research doses in animals often range from 1–2 μg/kg. In limited human research, 100 μg administered subcutaneously once or twice daily has been used. Hexarelin is not approved for therapeutic use.

Standard / Gradual Approach

standard
PhaseDoseVolume
Week 1100mcg
Week 2150mcg
Week 3200mcg
Week 4250mcg

Protocol Summary

Subcutaneous (SQ): Daily · Dose range 0.5–2 mcg with gradual titration
Intramuscular (IM): Twice daily · Dose range 1–3 mcg with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending

Frequency & Cycling

SubQ Injection

Administer daily or 5 days on, 2 days off. Cycle for 8–12 weeks with equal time off to prevent desensitization.

IM

Inject 1–2x daily, especially post-workout. Limit cycle to 6–10 weeks followed by GH recovery phase.

🧪 Quick Start

BAC Water
2 mL

Potential Benefits & Use Cases

Hexarelin is an investigational compound for research use only.
Strong GH release observed in both rodent and human studies
Studied for potential cardioprotective activity in preclinical models
Compared to other GHRPs for potency and desensitization rate
Investigated for wound healing and fat oxidation effects
Research interest in muscle wasting and neuroendocrine disorders
Clinical data Strong preclinical Limited data

Mechanism of Action

→Binds to ghrelin receptor (GHS-R1a)
→Stimulates release of growth hormone from the anterior pituitary
→Activates GH-dependent anabolic and lipolytic pathways

Lifestyle & Optimization

timing

Inject on empty stomach. Evening dose before bed.

diet

Caloric surplus with 1–1.2g protein per pound body weight.

exercise

Heavy resistance training for maximum GH-mediated muscle growth.

sleep

Sleep 8+ hours nightly for GH secretion optimization. Minimize stress and cortisol elevation.

Peptide Research & Preclinical Studies

Evidence-Based Research Findings

Study TitleType
The Safety and Efficacy of Growth Hormone SecretagoguesReference
Pharmacokinetics and Pharmacodynamic Effects of an Oral Ghrelin Agonist in Healthy SubjectsReference
The In Vivo Effect of Transcellular Permeation Enhancers on the Absorption of HexarelinReference

Side Effects & Safety

Common Side Effects

• Injection site irritation
• Mild headache
• Increased appetite

Contraindications & Warnings

• Potential increase in prolactin and cortisol at high doses
• Monitor for GH desensitization during prolonged use

Long-Term Safety Data

• May reduce endogenous GH response with long-term continuous use

🧮 Dose Calculator

Concentration
10.0
mcg/unit
Draw Volume
50
units (0.500 mL)
For a 500 mcg dose, draw 50 units on a U-100 insulin syringe
🧬

Bioavailability & Absorption

SubQ Injection
Hexarelin has high systemic absorption via subcutaneous route.
Oral Administration
Very poor bioavailability orally; requires permeability enhancers or alternate routes.
Half-Life
0.5–1 hour
Degradation
Primarily metabolized in the liver and kidneys.
Tissue Specificity
Affects pituitary, skeletal muscle, and adipose tissue.
⚗️

Peptide Details

Molecular Weight
887.04
Formula
C47H58N12O6
Sequence
H-Aib-His-D-2-Nal-Ala-Trp-D-Phe-2-Nal-Arg-Lys
⚖️

Legal Status & Regulatory

RegionStatus
FDANot Approved
EUNot Approved
AustraliaNot Approved
CanadaNot Approved

Storage Instructions

Lyophilized (Powder)
Store lyophilized powder at 2-8°C
Reconstituted (Mixed)
After reconstitution, maintain at 2-8°C and use within 28 days. Hexarelin is stable compared to other GH secretagogues.