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IGF-1 DES
Growth Factors & Muscle BuildingIGF-1 DES is a truncated, highly active form of IGF-1 with enhanced potency at muscle sites due to its low affinity for IGFBPs. It is studied for its potent anabolic signaling in muscle cells, especially during acute injury or mechanical overload in preclinical models.
Reconstitute
1 mL BAC + 1mg vial
10 mcg/unit
Daily Range
10–100 mcg Subcutaneous (SQ)
Daily
Standard Dose
50 mcg
Cycle
4–8 weeks
then reassess
IGF-1 DEStruncated IGFmuscle repairlocal growth factorpeptide therapy
Dosing & Reconstitution Guide
Rodent studies use IGF-1 DES in the range of 10–50 μg per site for localized muscle injection. These protocols are experimental and not suitable for clinical use.
Standard / Gradual Approach
standardPhaseDoseVolume
Week 120mcg
Week 240mcg
Week 360mcg
Week 480mcg
Protocol Summary
Subcutaneous (SQ): Daily · Dose range 10–100 mcg with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending
Frequency & Cycling
SubQ Injection
1–2x daily post-workout or site-specific application. Recommended cycle: 4–6 weeks on, followed by equal off-time to avoid IGF-1 receptor downregulation.
🧪 Quick Start
BAC Water
1 mL
Potential Benefits & Use Cases
IGF-1 DES is not approved for human use. Content presented is for informational and research purposes only.
Higher receptor binding affinity than IGF-1 LR3
Rapid-acting anabolic effects studied in muscle regeneration
Explored in tissue remodeling and recovery models
Used in vitro to evaluate cell growth and myogenesis
Short half-life supports localized, transient signaling
Clinical data Strong preclinical Limited data
Mechanism of Action
→Binds to IGF-1 receptors with higher affinity than native IGF-1
→Avoids IGF-binding proteins for greater local effect
→Stimulates protein synthesis and cell proliferation in muscle
Lifestyle & Optimization
timing
Inject immediately post-workout at target muscle site.
diet
Caloric surplus with high protein intake. Supplement with joint support (glucosamine, collagen).
exercise
Aggressive training program with emphasis on heavy compound lifts.
sleep
Sleep 8–10 hours nightly. Protect against injury during rapid muscle growth.
Peptide Research & Preclinical Studies
Evidence-Based Research Findings
Side Effects & Safety
Common Side Effects
• Hypoglycemia
• Injection site swelling or sensitivity
Contraindications & Warnings
• May induce insulin resistance in long-term use
• Avoid in individuals with cancer or at high cancer risk
Long-Term Safety Data
• Potential changes in insulin signaling pathways and glucose homeostasis
🧮 Dose Calculator
Concentration
10.0
mcg/unit
Draw Volume
50
units (0.500 mL)
For a 500 mcg dose, draw 50 units on a U-100 insulin syringe
🧬
Bioavailability & Absorption
SubQ Injection
High; preferred for localized tissue stimulation and systemic effect
Oral Administration
Not bioavailable due to GI tract degradation
Half-Life
20–30 minutes
Degradation
Rapidly degraded unless stabilized in cold-chain or modified carriers
Tissue Specificity
Acts at muscle repair sites and insulin-sensitive tissue
⚗️
Peptide Details
Molecular Weight
7491.4
Formula
C331H513N91O97S7
Sequence
Thr-Lys-Pro-Ser-Ser-Thr-Gln-Cys-Asn-Ser-Glu-Gln-Leu-Glu-R
⚖️
Legal Status & Regulatory
RegionStatus
FDANot Approved
EUNot Approved
AustraliaNot Approved
CanadaNot Approved
Storage Instructions
Lyophilized (Powder)
Store lyophilized powder at 2-8°C
Reconstituted (Mixed)
After reconstitution, with acetic acid, maintain at 2-8°C and use within 28 days. IGF-1 DES is more stable than standard IGF-1 but still requires acetic acid.