Back to Peptides

Ipamorelin

Growth Factors & Muscle Building

Ipamorelin is a highly selective GHRP with minimal side effects compared to earlier growth hormone secretagogues. It boosts natural GH secretion while avoiding significant stimulation of cortisol or prolactin. It has been investigated in both in vitro models and animal research for anti-aging, muscle recovery, and fat-loss protocols.

Reconstitute
2 mL BAC + 1mg vial
5 mcg/unit
Daily Range
100–300 mcg Subcutaneous (SQ)
1-3 times daily (typically at bedtime)
Standard Dose
200 mcg
Cycle
4–8 weeks
then reassess
Ipamorelingrowth hormonepeptide therapyGH secretagoguemuscle recoveryfat loss

Dosing & Reconstitution Guide

Rodent protocols typically use doses of 100–200 μg/kg administered subcutaneously. These figures do not represent safe or approved human dosing.

Standard / Gradual Approach

standard
PhaseDoseVolume
Week 1100mcg
Week 2150mcg
Week 3200mcg
Week 4300mcg

Protocol Summary

Subcutaneous (SQ): 1-3 times daily (typically at bedtime) · Dose range 100–300 mcg with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending

Frequency & Cycling

SubQ Injection

200 mcg nightly (5 nights on, 2 nights off) or 200–300 mcg up to 3x/day. Limit use to 8-week cycles followed by equal off time to maintain pituitary sensitivity.

🧪 Quick Start

BAC Water
2 mL

Potential Benefits & Use Cases

Ipamorelin is a research-use-only peptide not approved for human or veterinary application.
Supports increases in lean body mass and improvements in recovery through GH-mediated processes (preclinical)
Enhances fat metabolism and supports favorable body composition changes (preclinical)
Highly selective for GH release with minimal impact on ACTH, cortisol, or prolactin (human trial)
May support improved gastric motility and digestive function (preclinical)
Supports deeper, more restorative sleep through GH pulse enhancement (preclinical)
Promotes joint, tendon, and ligament repair through GH/IGF-1 pathways (preclinical)
Clinical data Strong preclinical Limited data

Mechanism of Action

→Selective GHRP receptor agonist
→Stimulates endogenous GH secretion via ghrelin-mimetic action
→Low activity on ACTH, cortisol, and prolactin secretion

Lifestyle & Optimization

timing

Inject on empty stomach (2–3 hours post-meal). Evening dose before bed preferred.

diet

Adequate protein (1–1.2g per pound body weight). Slight caloric surplus for muscle gains.

exercise

Resistance training 4–5 times weekly with focus on compound movements.

sleep

Prioritize 7–9 hours of sleep for GH secretion.

Peptide Research & Preclinical Studies

Evidence-Based Research Findings

Study TitleType
Translational Andrology and Urology (PMC) — GH secretagogues in hypogonadal malesReference
European Journal of Endocrinology — Ipamorelin, first selective GH secretagogueReference
European Journal of Anatomy — Chronic Ipamorelin treatmentReference
Pharmaceutical Research — Pharmacokinetic-pharmacodynamic modelingReference
International Journal of Colorectal Disease — Ipamorelin for postoperative ileusReference

Side Effects & Safety

Common Side Effects

• Mild nausea, especially first week
• Headaches, lightheadedness
• Water retention and bloating (dose-dependent)
• Increased appetite

Long-Term Safety Data

• Potential insulin resistance with heavy prolonged use

🧮 Dose Calculator

Concentration
5.0
mcg/unit
Draw Volume
100
units (1.000 mL)
For a 500 mcg dose, draw 100 units on a U-100 insulin syringe
🧬

Bioavailability & Absorption

SubQ Injection
High; effective peak achieved with rapid uptake and consistent GH stimulation
Oral Administration
Poor bioavailability due to proteolysis
Half-Life
Approximately 2 hours
Degradation
Metabolized hepatically and cleared renally
Tissue Specificity
Affects GH-receptor expressing tissues like muscle, adipose, and connective tissue
⚗️

Peptide Details

Molecular Weight
711.86
Formula
C38H49N9O5
Sequence
Aib-His-2-methyl-L-tyrosine-D-lysino-D-alaninamide
⚖️

Legal Status & Regulatory

RegionStatus
FDANot Approved
EUNot Approved
AustraliaNot Approved
CanadaNot Approved

Storage Instructions

Lyophilized (Powder)
Store lyophilized powder at 2-8°C
Reconstituted (Mixed)
After reconstitution, maintain at 2-8°C and use within 30 days. Ipamorelin is one of the more stable peptides.