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MGF (Mechano Growth Factor)
Growth Factors & Muscle BuildingMGF (Mechano Growth Factor) is an IGF-1 splice variant upregulated in muscle post-injury or resistance training. It activates muscle satellite cells, facilitating localized tissue repair and hypertrophy. PEGylated forms are used to extend its half-life and improve delivery. It has been studied in vitro and in animal models for its role in muscle regeneration and tissue growth signaling.
Reconstitute
3 mL BAC + 2mg vial
7 mcg/unit
Daily Range
100–400 mcg Subcutaneous (SQ)
2-3x weekly, post-exercise
Standard Dose
200 mcg
Cycle
4–8 weeks
then reassess
MGFMechano Growth FactorIGF-1 splice variantmuscle regenerationpost-exercise recovery
Dosing & Reconstitution Guide
Doses used in research range from 50–200 μg per site in rodent models. Injections are often administered intramuscularly immediately post-exercise in lab settings. MGF is not approved for therapeutic use in humans.
Standard / Gradual Approach
5mg VialstandardPhaseDoseVolume
Week 1100 mcg (0.1 mg)6 units (0.06 mL)
Week 2150 mcg (0.15 mg)9 units (0.09 mL)
Week 3200 mcg (0.2 mg)12 units (0.12 mL)
Week 4250 mcg (0.25 mg)15 units (0.15 mL)
Weeks 5–8300 mcg (0.3 mg)18 units (0.18 mL)
Protocol Summary
Subcutaneous (SQ): 2-3x weekly, post-exercise · Dose range 100–400 mcg with gradual titration
Intramuscular (IM): 2-3x weekly, post-exercise · Dose range 200–800 mcg with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending
Frequency & Cycling
SubQ Injection
2–3x weekly, immediately post-training. Typical cycle: 6–12 weeks followed by 4-week off period to restore GH sensitivity.
IM Injection
Inject post-exercise into the trained muscle group for targeted effect. Use in cycles and avoid continuous year-round application.
🧪 Quick Start
Vial Size
2 mg
BAC Water
3 mL
Concentration
0.67 mcg/unit
Starting Dose
100 mcg bilaterally post-workout
Maintenance Dose
200 mcg bilaterally post-workout
Potential Benefits & Use Cases
MGF is an experimental peptide compound not intended for human use.
Promotes satellite cell activation and myoblast proliferation — extends proliferative lifespan (preclinical)
Supports bone defect healing and osteoblast activation (preclinical)
Promotes neurogenesis in hippocampus and subventricular zone of aging brain tissue (preclinical)
Preserves olfactory function into old age in overexpression models (preclinical)
Improves motor neuron survival in ALS models (preclinical)
Avoids oncogenic side effects of full IGF-1 (preclinical)
Clinical data Strong preclinical Limited data
Mechanism of Action
→Splice variant of IGF-1 activated by mechanical stress
→Increases satellite cell activation and muscle protein synthesis
→Promotes muscle regeneration in damaged tissue
→Works independently of systemic IGF-1 in early repair phases
Lifestyle & Optimization
timing
Inject immediately post-workout at target muscle site.
diet
Adequate protein (1.6–2.2 g/kg).
exercise
Pair with resistance training — mechanical stimulus upregulates MGF.
sleep
Prioritize sleep and recovery. Manage inflammation.
Peptide Research & Preclinical Studies
Evidence-Based Research Findings
Study TitleType
Side Effects & Safety
Common Side Effects
• Fatigue/flu-like symptoms at higher doses (user-reported)
• Muscle tightness and cramps at injection site (user-reported)
• Water retention, hypoglycemia — most reported systemic effect (user-reported)
• Nausea, dry mouth (user-reported)
Contraindications & Warnings
• Risk of excessive tissue growth if overused (theoretical)
🧮 Dose Calculator
Concentration
6.7
mcg/unit
Draw Volume
75
units (0.750 mL)
For a 500 mcg dose, draw 75 units on a U-100 insulin syringe
🧬
Bioavailability & Absorption
SubQ Injection
Effective localized delivery for post-workout repair
Oral Administration
Not orally bioavailable; degraded in GI tract
Intranasal
N/A
Half-Life
5–7 minutes unmodified; longer with PEGylation
Degradation
Metabolized hepatically and renally
Tissue Specificity
Highly targeted to skeletal muscle repair pathways
⚗️
Peptide Details
Molecular Weight
2867.36
Formula
C121H200N42O39
Sequence
PEGylated IGF-1 Ec variant
⚖️
Legal Status & Regulatory
RegionStatus
FDANot Approved
EUNot Approved
AustraliaNot Approved
CanadaNot Approved
Storage Instructions
Lyophilized (Powder)
Store lyophilized powder at -20°C for long-term storage. Very temperature-sensitive peptide. Do not freeze reconstituted solution. MGF degrades quickly at room temperature.
Reconstituted (Mixed)
Refrigerate at 2-8°C. Use within 2-3 weeks.