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N-Acetyl Epithalon Amidate
Anti-Aging & Skin HealthN-Acetyl Epithalon Amidate is a bioavailable synthetic peptide analog of Epitalon designed to support DNA repair, telomere lengthening, and pineal regulation. It may improve sleep, boost cognitive performance, and delay signs of biological aging through epigenetic and circadian mechanisms in animal models.
Reconstitute
3 mL BAC + 10mg vial
33 mcg/unit
Daily Range
100–1000 mcg Subcutaneous (SQ)
Daily
Standard Dose
300 mcg
Cycle
4–8 weeks
then reassess
EpithalonN-Acetyl Epitalon Amidatetelomerase activatorlongevity peptidepineal regulation
Dosing & Reconstitution Guide
Animal studies used 1–10 mg/kg via subcutaneous or intraperitoneal injection. No human dosing data is approved.
Standard / Gradual Approach
10mg VialstandardPhaseDoseVolume
Week 1-25 mg daily
Week 3-45-10 mg daily
Week 5+10 mg daily for 10-20 days, cycle off for 4-6 months
Protocol Summary
Subcutaneous (SQ): Daily · Dose range 100–1000 mcg with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending
Frequency & Cycling
SubQ Injection
Cycle: 8–10 weeks daily, followed by 2–4 month break. Protocol may repeat 1–2x annually.
🧪 Quick Start
Vial Size
10 mg
BAC Water
3 mL
Concentration
3.33 mcg/unit
Starting Dose
5 mg daily
Maintenance Dose
5-10 mg daily
Potential Benefits & Use Cases
This compound is for research use only. It is not authorized for use in human anti-aging therapies.
Supports telomere maintenance through telomerase activation — significant telomere length increases in patients aged 60–80 (human trial)
Restores healthy melatonin production and circadian rhythm regulation (preclinical)
Extended lifespan and reduced tumor incidence in animal models (preclinical)
Improved cardiovascular outcomes and reduced mortality over 12-year follow-up (human trial)
90% of retinitis pigmentosa patients showed positive clinical effects in trial (human trial)
Clinical data Strong preclinical Limited data
Mechanism of Action
→Upregulates telomerase gene (TERT) expression and telomere stabilization
→Modulates circadian rhythm gene clusters via pineal axis signaling
→Regulates chromatin and epigenetic transcription pathways
→Activates protein synthesis during neurogenesis and tissue repair
Lifestyle & Optimization
timing
Morning or early afternoon administration recommended
diet
No specific dietary requirements. Antioxidant-rich diet may support telomere health.
exercise
Regular moderate exercise supports telomerase activity.
sleep
Adequate sleep supports the longevity and telomere maintenance effects.
Peptide Research & Preclinical Studies
Evidence-Based Research Findings
Study TitleType
Wikipedia — Epitalon overviewReference
Side Effects & Safety
Common Side Effects
• Transient sleep pattern changes may occur
🧮 Dose Calculator
Concentration
33.3
mcg/unit
Draw Volume
15
units (0.150 mL)
For a 500 mcg dose, draw 15 units on a U-100 insulin syringe
🧬
Bioavailability & Absorption
SubQ Injection
High with effective systemic and pineal delivery
Oral Administration
Low bioavailability without protective carriers
Half-Life
4 hours
Degradation
Metabolized by peptidases and cleared via renal excretion
Tissue Specificity
Pineal gland, hippocampus, retina, and hypothalamus
⚗️
Peptide Details
Molecular Weight
519.69
Formula
C28H45N5O4
Sequence
N-acetyl-Ala-Glu-Asp-Gly-amidate
⚖️
Legal Status & Regulatory
RegionStatus
FDANot Approved
EUNot Approved
AustraliaNot Approved
CanadaNot Approved
Storage Instructions
Lyophilized (Powder)
Store lyophilized powder at -20°C for long-term or 2-8°C for up to 12 months. Protect from light. Do not freeze reconstituted solution.
Reconstituted (Mixed)
Refrigerate at 2-8°C. Use within 4 weeks.