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PAL-GHK
Anti-Aging & Skin HealthPAL-GHK is a lipopeptide derivative of the GHK sequence used in skin rejuvenation. It improves collagen synthesis, reduces signs of aging, and promotes epidermal repair. PAL-GHK is commonly found in cosmetic serums and creams for daily use to restore youthful skin structure and reduce inflammation.
Reconstitute
2 mL BAC + 10mg vial
50 mcg/unit
Daily Range
0.5–2 % Topical
Once or twice daily
Standard Dose
1 %
Cycle
4–8 weeks
then reassess
PAL-GHKlipopeptidecollagen synthesiscosmetic peptideanti-aging
Dosing & Reconstitution Guide
Commonly used in commercial cosmetic products at 2–5% concentration. It is not approved for injection or therapeutic use.
Standard / Gradual Approach
10mg VialstandardPhaseDoseVolume
Week 1100mcg2 units
Week 2150mcg3 units
Week 3200mcg4 units
Week 4250mcg5 units
Protocol Summary
Topical: Once or twice daily · Dose range 0.5–2 % with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending
Frequency & Cycling
Topical
Apply once or twice daily. Continuous use for 8–12 weeks recommended for optimal cosmetic benefit. Maintenance use can follow at 1x daily.
🧪 Quick Start
Vial Size
10 mg
BAC Water
2 mL
Concentration
5000 mcg/unit
Potential Benefits & Use Cases
PAL-GHK is a cosmetic research peptide, not approved for injectable or therapeutic use.
Enhances skin firmness and elasticity in cosmetic models
Stimulates collagen, elastin, and glycosaminoglycan synthesis
Used in anti-aging skincare products for wrinkle reduction
Lipidation improves skin absorption and bioavailability
Non-toxic and well-tolerated in topical application studies
Clinical data Strong preclinical Limited data
Mechanism of Action
→Enhances extracellular matrix (ECM) activity by stimulating fibroblasts
→Upregulates genes associated with skin regeneration and repair
→Suppresses pro-inflammatory cytokines and oxidative enzymes
→Promotes angiogenesis and glycosaminoglycan (GAG) synthesis
Stacking Synergies
+
GHK-Cu
Enhances overall skin tone and anti-aging benefits when combined with GHK-Cu
+
BPC-157
Combines well with BPC-157 for wound healing and epithelial restoration
Lifestyle & Optimization
diet
Adequate water intake (2–3 liters daily). Include collagen-rich foods.
sleep
Sleep 7–9 hours nightly for tissue repair. Protect skin from excessive sun exposure.
timing
Topical daily application or consistent SubQ schedule.
exercise
Moderate activity as tolerated.
Peptide Research & Preclinical Studies
Evidence-Based Research Findings
Side Effects & Safety
Common Side Effects
• Mild irritation or redness at application site
• Temporary dryness or tingling
Contraindications & Warnings
• Patch test recommended before use in individuals with sensitive skin or rosacea
Long-Term Safety Data
• Well tolerated in long-term cosmetic use; no systemic adverse effects reported
🧮 Dose Calculator
Concentration
50.0
mcg/unit
Draw Volume
10
units (0.100 mL)
For a 500 mcg dose, draw 10 units on a U-100 insulin syringe
🧬
Bioavailability & Absorption
SubQ Injection
Rarely used; not formulated for injection
Oral Administration
Not viable orally; no clinical bioavailability via GI tract
Half-Life
Not clearly defined in topical use
Degradation
Metabolized locally by skin enzymes
Tissue Specificity
Targets dermis and epidermis for skin regeneration and anti-aging
⚗️
Peptide Details
Molecular Weight
578
Formula
C30H54N6O9
Sequence
Palmitoyl-Gly-His-Lys
⚖️
Legal Status & Regulatory
RegionStatus
EUNot Approved
FDANot Approved
CanadaNot Approved
AustraliaNot Approved
Storage Instructions
Lyophilized (Powder)
Store lyophilized powder at -20°C for long-term storage, or at 2-8°C for short-term
Reconstituted (Mixed)
After reconstitution, maintain at 2-8°C and use within 30 days. Protect from light exposure.