Back to Peptides
Pinealon
Neuroprotective & Cognitive EnhancersPinealon is a synthetic tripeptide bioregulator derived from pineal and brain tissue that promotes neuroprotection, memory consolidation, and pineal gland function. It is used in aging, cognitive decline, and circadian rhythm regulation protocols and has demonstrated antioxidant and geroprotective properties in preclinical studies.
Reconstitute
3 mL BAC + 20mg vial
67 mcg/unit
Daily Range
3–10 mcg Subcutaneous (SQ)
Daily
Standard Dose
5 mcg
Cycle
4–8 weeks
then reassess
Pinealonpineal peptidenootropiccognitive enhancementcircadian rhythm
Dosing & Reconstitution Guide
In animal studies, Pinealon is typically used at doses of 100–300 μg/kg via injection. Clinical equivalents are unvalidated.
Standard / Gradual Approach
20mg VialstandardPhaseDoseVolume
Weeks 1–2200 mcg (0.20 mg)3 units (0.03 mL)
Weeks 3–4300 mcg (0.30 mg)4.5 units (0.045 mL)
Weeks 5–6400 mcg (0.40 mg)6 units (0.06 mL)
Weeks 7–12500 mcg (0.50 mg)7.5 units (0.075 mL)
Protocol Summary
Subcutaneous (SQ): Daily · Dose range 3–10 mcg with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending
Frequency & Cycling
SubQ Injection
Administer daily for 10–20 days. Repeat every 4–6 months for cognitive maintenance or aging support.
🧪 Quick Start
Vial Size
20 mg
BAC Water
3 mL
Concentration
6.67 mcg/unit
Starting Dose
200 mcg (0.20 mg) (3 units (0.03 mL))
Maintenance Dose
500 mcg (0.50 mg) (7.5 units (0.075 mL))
Potential Benefits & Use Cases
Pinealon is a research peptide not approved for human or therapeutic use. All information reflects experimental findings.
Demonstrates neuroprotective and anti-oxidative effects in brain tissue models (preclinical)
Modulates epigenetic markers and preserves neuronal structures (spines and synapses) (preclinical)
Improves working memory in 59.4% of subjects in clinical study (limited human data)
Shows benefit in traumatic brain injury recovery — improved memory and cognitive performance in 72 TBI patients (limited human data)
Suppresses ROS accumulation and activates antioxidant enzyme synthesis in cerebellar neurons (preclinical)
Clinical data Strong preclinical Limited data
Mechanism of Action
→Crosses the blood-brain barrier and enhances neural gene expression
→Supports pineal gland-mediated hormonal balance (e.g., melatonin)
→Increases resistance of neurons to oxidative stress and metabolic damage
→Stabilizes bioelectrical activity in cerebral cortex and hippocampus
Lifestyle & Optimization
timing
Standardize sleep-wake windows. Evening dosing may support melatonin production.
diet
Maintain consistent nutrition. Minimize caffeine and alcohol.
exercise
Moderate activity.
sleep
Track outcomes with validated cognitive tools.
Peptide Research & Preclinical Studies
Evidence-Based Research Findings
Study TitleType
Side Effects & Safety
Common Side Effects
• Headaches (tension-like)
• Vivid dreams/insomnia if taken late
• Mild anxiety, dizziness, nausea
• Changes in bowel habits
🧮 Dose Calculator
Concentration
66.7
mcg/unit
Draw Volume
7
units (0.070 mL)
For a 500 mcg dose, draw 7 units on a U-100 insulin syringe
🧬
Bioavailability & Absorption
SubQ Injection
High systemic bioavailability with direct delivery to central circulation
Oral Administration
Low; degraded in GI tract unless encapsulated or nano-formulated
Half-Life
Approximately 20 minutes
Degradation
Metabolized by tissue peptidases and liver enzymes
Tissue Specificity
Targets pineal gland, hippocampus, and neocortex
⚗️
Peptide Details
Molecular Weight
200.25
Formula
C10H16N2O3
Sequence
Lys-Gly-Asn
⚖️
Legal Status & Regulatory
RegionStatus
FDANot Approved
EUNot Approved
AustraliaNot Approved
CanadaNot Approved
Storage Instructions
Lyophilized (Powder)
store at −20 °C (−4 °F) protected from light; after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); minimize freeze–thaw cycles
Reconstituted (Mixed)
Refrigerate at 2–8 °C (35.6–46.4 °F); aliquot if needed and avoid freeze–thaw