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Retatrutide Dosage Guide

Complete dosing protocol, reconstitution steps, and interactive calculator for Retatrutide.

Dosing & Reconstitution Guide

Clinical trials have tested weekly subcutaneous doses ranging from 4–12 mg. These are experimental protocols under FDA supervision

Standard / Gradual Approach

30mg Vialstandard
PhaseDoseVolume
Weeks 1–42,000 mcg (2 mg)20 units (0.20 mL)
Weeks 5–84,000 mcg (4 mg)40 units (0.40 mL)
Weeks 9–128,000 mcg (8 mg)80 units (0.80 mL)
Weeks 13+12,000 mcg (12 mg)120 units (1.20 mL) — split into 2 injections or use 2 vials

Standard / Gradual Approach

30mg Vialstandard
PhaseDoseVolume
Weeks 1–42,000 mcg (2 mg)20 units (0.20 mL)
Weeks 5–84,000 mcg (4 mg)40 units (0.40 mL)
Weeks 9–128,000 mcg (8 mg)80 units (0.80 mL)
Weeks 13+12,000 mcg (12 mg)120 units (1.20 mL) — split into 2 injections or use 2 vials

Standard / Gradual Approach

10mg Vialstandard
PhaseDoseVolume
Weeks 1–42,000 mcg (2 mg)40 units (0.40 mL)
Weeks 5–84,000 mcg (4 mg)80 units (0.80 mL)
Weeks 9–128,000 mcg (8 mg)160 units (1.60 mL) — use 2 vials or split injection
Weeks 13+12,000 mcg (12 mg)240 units (2.40 mL) — use 2 vials or split injection

Standard / Gradual Approach

5mg Vialstandard
PhaseDoseVolume
Weeks 1–42,000 mcg (2 mg)80 units (0.80 mL)
Weeks 5–84,000 mcg (4 mg)160 units (1.60 mL) — use 2 vials
Weeks 9–128,000 mcg (8 mg)320 units (3.20 mL) — use 2 vials
Weeks 13+12,000 mcg (12 mg)480 units (4.80 mL) — use 3 vials

Protocol Summary

Subcutaneous (SQ): Once weekly · Dose range 2–12 mg with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending

Frequency & Cycling

Subcutaneous

Retatrutide is dosed weekly, typically starting at 2 mg for the first 4 weeks, then increasing by 2 mg increments every 4 weeks up to 12 mg. Overlapping with other incretin-based therapies (like GLP-1 or GIP agonists) should be avoided unless supervised.

🧪 Quick Start

Vial Size
12 mg
BAC Water
3 mL
Concentration
4000 mcg/unit
Starting Dose
2,000 mcg (2 mg) (20 units (0.20 mL))
Maintenance Dose
12,000 mcg (12 mg) (120 units (1.20 mL) — split into 2 injections or use 2 vials)

🧮 Dose Calculator

Concentration
40.0
mcg/unit
Draw Volume
13
units (0.130 mL)
For a 500 mcg dose, draw 13 units on a U-100 insulin syringe