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Setmelanotide Dosage Guide
Complete dosing protocol, reconstitution steps, and interactive calculator for Setmelanotide.
Dosing & Reconstitution Guide
Maximum dose typically 20mg daily. Monitor for skin darkening and other melanocortin-mediated effects. Discontinue if severe adverse effects occur.
Standard / Gradual Approach
10mg VialstandardPhaseDoseVolume
Week 11mg
Week 22mg
Week 33mg
Week 44mg
Protocol Summary
Subcutaneous (SQ): Once daily · Dose range 1–3 mg with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending
Frequency & Cycling
SubQ Injection
Administered once daily. Initiate at 1 mg and titrate to 2–3 mg based on response. Long-term or continuous use is permitted with regular monitoring of BMI, leptin response, appetite suppression, and metabolic labs. Typically not cycled unless due to tolerability issues or therapeutic plateau.
🧪 Quick Start
Vial Size
10 mg
🧮 Dose Calculator
Concentration
50.0
mcg/unit
Draw Volume
10
units (0.100 mL)
For a 500 mcg dose, draw 10 units on a U-100 insulin syringe