Back to SS-31
SS-31 Dosage Guide
Complete dosing protocol, reconstitution steps, and interactive calculator for SS-31.
Dosing & Reconstitution Guide
In preclinical studies, SS-31 has been administered at 3–10 mg/kg. Clinical trials have explored IV administration at doses up to 0.25 mg/kg. These uses are investigational only.
Standard / Gradual Approach
150mg VialstandardPhaseDoseVolume
Weeks 1–210 mg (10,000 mcg)20 units (0.20 mL)
Weeks 3–420 mg (20,000 mcg)40 units (0.40 mL)
Weeks 5–830 mg (30,000 mcg)60 units (0.60 mL)
Weeks 9–12+40 mg (40,000 mcg)80 units (0.80 mL)
Standard / Gradual Approach
150mg VialadvancedPhaseDoseVolume
Weeks 1–220 mg (20,000 mcg)40 units (0.40 mL)
Weeks 3–12+40 mg (40,000 mcg)80 units (0.80 mL)
Standard / Gradual Approach
90.9mg VialstandardPhaseDoseVolume
Weeks 1–210 mg (10,000 mcg)33 units (0.33 mL)
Weeks 3–420 mg (20,000 mcg)67 units (0.67 mL)
Weeks 5–8+30 mg (30,000 mcg)100 units (1.0 mL)
Protocol Summary
Intravenous (IV): Single IV infusion (clinical/research setting) · Dose range 0.05–0.25 mg with gradual titration
Subcutaneous (SQ): Once daily · Dose range 20–40 mg with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending
Frequency & Cycling
IV
Typical cycle length is 4–12 weeks, with reassessment of mitochondrial function after the cycle.
Subcutaneous
Cycle: 4–6 weeks on, then 2–4 weeks off Morning dosing is most common. Some researchers use 0.1–1mg daily for microdosing. Often used as a primer before MOTS-c.
🧪 Quick Start
Vial Size
25 mg
BAC Water
3 mL
Concentration
8300 mcg/unit
Starting Dose
5 mg (5000 mcg) (30 units (0.30 mL))
Maintenance Dose
10 mg (10,000 mcg) (60 units (0.60 mL))
🧮 Dose Calculator
Concentration
83.3
mcg/unit
Draw Volume
6
units (0.060 mL)
For a 500 mcg dose, draw 6 units on a U-100 insulin syringe