Gonadorelin

Gonadorelin is a synthetic gonadotropin-releasing hormone (GnRH) used for diagnostic and therapeutic purposes in reproductive and endocrine medicine. It stimulates the anterior pituitary to release LH and FSH and is used in fertility restoration, hormone replacement, and hypothalamic amenorrhea treatment.

• Acts as a GnRH receptor agonist on the anterior pituitary
• Induces secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)
• Requires pulsatile administration to mimic physiological GnRH signaling
• Used in evaluating pituitary response and stimulating gonadal steroid production

• unit: mg

  low dose: 0.05

  frequency: Single dose (diagnostic) or pulsatile dosing (therapeutic)

  high dose: 0.2

  standard dose: 0.1

  administration route: Intravenous (IV)

• For diagnostic use: 0.1 mg IV as a single bolus. For therapeutic use: administered every 90–120 min in pulsatile infusion pumps over 7–14 days.

common: ["Transient headache or flushing shortly after injection"]

sequence: Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

half life: 2–4 minutes

degradation: Rapid degradation by plasma proteases and renal clearance

molecular weight: 1182

molecular formula: C55H75N17O13

tissue specificity: Targets anterior pituitary GnRH receptors

• GnRH agonists: gonadorelin, leuprolide and nafarelin.reviewPMID 1835275 ↗
• Effect of gonadorelin (GnRH) products on pregnancy rates in postpartum dairy cows.clinicalPMID 25979657 ↗