Low-T / hypogonadism / TRT support
Restore/protect the gonadal axis rather than replace downstream hormones.
Decision support, not prescription. You decide.
Candidate agents
3 agents · ranked by role, then evidenceIn hypogonadal men, hCG's LH-like action stimulates endogenous Leydig-cell testosterone and, co-administered with TRT, maintains intratesticular testosterone and semen parameters, preventing TRT-induced azoospermia.
PMID 23260550Pulsatile gonadorelin restores endogenous LH/FSH and testosterone in congenital hypogonadotropic hypogonadism; a pump regimen induced spermatogenesis earlier (median 6 vs 14 mo) with more physiologic testosterone than gonadotropin therapy.
PMID 30569789IV kisspeptin-10 increased LH pulse frequency, LH secretion, and serum testosterone in hypotestosteronaemic men with type 2 diabetes, indicating a potential therapeutic role for kisspeptin agonists in central hypogonadism.
PMID 23153270Matching protocol templates
Browse all →Reset endogenous hormone production and modulate pituitary signaling
Restore endogenous testosterone and support natural HPTA recovery
Natural testosterone restoration, fertility support, HPTA recovery
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