MGF (Mechano Growth Factor)

MGF (Mechano Growth Factor) is an IGF-1 splice variant upregulated in muscle post-injury or resistance training. It activates muscle satellite cells, facilitating localized tissue repair and hypertrophy. PEGylated forms are used to extend its half-life and improve delivery. It has been studied in vitro and in animal models for its role in muscle regeneration and tissue growth signaling.

• Splice variant of IGF-1 activated by mechanical stress
• Increases satellite cell activation and muscle protein synthesis
• Promotes muscle regeneration in damaged tissue
• Works independently of systemic IGF-1 in early repair phases

• unit: mcg

  low dose: 100

  frequency: 2-3x weekly, post-exercise

  high dose: 400

  standard dose: 200

  administration route: Subcutaneous (SQ)

• unit: mcg

  low dose: 200

  frequency: 2-3x weekly, post-exercise

  high dose: 800

  standard dose: 400

  administration route: Intramuscular (IM)

• 2–3x weekly, immediately post-training. Typical cycle: 6–12 weeks followed by 4-week off period to restore GH sensitivity.
• Inject post-exercise into the trained muscle group for targeted effect. Use in cycles and avoid continuous year-round application.

common: ["Fatigue/flu-like symptoms at higher doses (user-reported)","Muscle tightness and cramps at injection site (user-reported)","Water retention, hypoglycemia — most reported systemic effect (user-reported)","Nausea, dry mouth (user-reported)"]

warnings: ["Risk of excessive tissue growth if overused (theoretical)"]

sequence: PEGylated IGF-1 Ec variant

half life: 5–7 minutes unmodified; longer with PEGylation

degradation: Metabolized hepatically and renally

molecular weight: 2867.36

molecular formula: C121H200N42O39

tissue specificity: Highly targeted to skeletal muscle repair pathways

• Mechano growth factor, a splice variant of IGF-1, promotes neurogenesis in the aging mouse brain.preclinicalPMID 28683812 ↗
• Mechano-growth factor: a product of IGF-I gene expression involved in tissue repair.reviewPMID 20130113 ↗