Thymosin Beta-4

Thymosin Beta-4 is an endogenous peptide critical for cellular repair and cytoskeletal regulation. It plays a key role in tissue regeneration, inflammation control, and angiogenesis. Distinct from synthetic TB-500 fragments, full-length TB4 is being studied for cardiac recovery, neurological healing, and advanced wound care.

• Binds to G-actin, promoting cell migration and cytoskeletal remodeling
• Activates integrin-linked kinase (ILK) for tissue repair signaling
• Increases VEGF expression to stimulate angiogenesis
• Downregulates pro-inflammatory cytokines and chemokines in damaged tissue

• unit: mg

  low dose: 1

  frequency: 1–2x weekly

  high dose: 4

  standard dose: 2

  administration route: Subcutaneous (SQ)

• Loading phase: 2–4 mg SubQ twice weekly for 2–4 weeks. Maintenance phase: 2 mg weekly as needed. Cycles repeated based on injury severity or recovery goals.

common: ["Injection site redness","Mild fatigue"]

warnings: ["Not recommended in individuals with active malignancies due to its angiogenic effects"]

long term: ["No adverse long-term effects reported in animal models; human data limited"]

sequence: Ac-Ser-Asp-Lys-Pro-Thr-Phe-Ser-Pro-Lys-Glu-Lys-Lys-Cys-Asp-Glu-Leu-Ser-Lys-Leu-Tyr-Glu-Asp-Gly-Asp-Tyr-Phe-Ser-Asp-Cys-Phe-Leu-Cys-His-Val

half life: 2–3 hours

degradation: Cleared by renal excretion and protease metabolism

molecular weight: 4963.49

molecular formula: C212H350N56O78S

tissue specificity: Tissues undergoing damage, inflammation, or requiring regenerative cues: heart, skin, brain, cornea, tendons

• Thymosin beta4: a multi-functional regenerative peptide. Basic properties and clinical applications.reviewPMID 22074294 ↗
• Thymosin Beta-4 Modulates Cardiac Remodeling by Regulating ROCK1 Expression.mechanismPMID 40362372 ↗
• Thymosin beta 4 and the eye: the journey from bench to bedside.clinicalPMID 30063853 ↗