Hashimoto's
Zero human RCTs; gut-axis least-speculative; layer on levothyroxine, never replace.
Decision support, not prescription. You decide.
Warning — Thymosin α-1 bidirectional in autoimmune thyroid
The only autoimmune-thyroid study showed Tα-1 worsened disease in some hosts — may aggravate. Do not lead with it.
Candidate agents
2 agents · ranked by role, then evidenceWarning — Thymosin α-1 bidirectional in autoimmune thyroid
Only autoimmune-thyroid study (mouse EAT) was bidirectional — suppressed OR worsened by host/timing.
PMID 3873993Zonulin/barrier blockade prevented autoimmunity onset in a preclinical arthritis model — proof-of-concept for the leaky-gut→autoimmunity hypothesis; no thyroid data. (Human larazotide data exists in celiac — separate ref, add on verification.)
PMID 32332732Matching protocol templates
Browse all →Neuroimmune balance and fatigue recovery
Immune recalibration and systemic recovery
Immune reset, energy restoration, and cytokine balance in autoimmune or fatigue syndromes
The platform surfaces evidence, community signal and peer outcomes with enforced cautions. It never decides treatment — the licensed clinician orders labs, writes notes, and prescribes.